Weight Gain Post-GLP-1
Let’s talk about what happens when people stop taking GLP-1 medications for weight management. Some folks notice the numbers on the scale start to climb again, while others manage to keep the weight off. It’s not about willpower or doing something wrong. The truth is, our bodies are complex, and weight loss is rarely straightforward. Let’s look at what the science says—and how you can use that knowledge to feel empowered.
Why Weight Can Come Back
GLP-1 medications work by sending signals to your brain to feel full, slowing digestion, and balancing blood sugar. For a while, you might notice you’re not as hungry and you’re making healthier choices more easily. But when you stop taking the medication, those helpful signals fade.
Recent research shows that weight regain after stopping GLP-1 meds is common and can happen fairly quickly. One large study followed over 125,000 adults with overweight or obesity who started GLP-1 receptor agonists like semaglutide or tirzepatide. It found that most people discontinued the medication within a year, and those who stopped often regained weight. Weight gain after stopping was linked to a higher chance of restarting the medication.
Another analysis of the SURMOUNT-1 trial found that nearly 73% of participants regained weight within 17 weeks after stopping tirzepatide, highlighting how quickly the body can revert when the drug is discontinued.
A meta-analysis confirmed that after stopping GLP-1 receptor agonists, people regained weight rapidly—about 0.7 to 0.8 kilograms per month—resulting in nearly full return to baseline weight within 1 to 2 years.
This happens because when you lose weight, your body responds by slowing metabolism and increasing hunger hormones like ghrelin. Muscle loss during rapid weight loss can also lower your resting metabolic rate, making it easier to regain weight.
Why Some People Keep the Weight Off
Not everyone regains weight at the same rate or to the same extent. Research shows that people who maintain weight loss after stopping GLP-1 meds often have developed sustainable habits like regular strength training, balanced meals rich in protein and fiber, and mindful eating practices. Combining medication with lifestyle changes is key to long-term success.
Gentle Strategies for Lasting Success
If you’re thinking about stopping GLP-1 medications or have already stopped, here are some compassionate, practical ideas based on recent evidence and real-world experience:
· Transition Slowly
Tapering off the medication gradually with your doctor’s guidance can help your body adjust. Patients who tapered semaglutide over several weeks maintained more stable weight afterward.
· Protect Your Metabolism
Incorporate strength training 2 to 3 times a week to preserve muscle mass, which supports metabolism. Pair this with protein-rich meals to help keep you full and maintain muscle.
· Mindful Eating
Slow down and savor your food. Paying close attention to the experience of eating can reduce calorie intake naturally and improve satisfaction.
· Prioritize Sleep and Stress Management
Poor sleep and high stress can increase hunger hormones and cravings. Aim for restful sleep and find calming routines that work for you.
· Celebrate Non-Scale Victories
Notice improvements in energy, mood, and how your clothes fit. These are important markers of health beyond the number on the scale.
· Seek Support
Whether it’s a nutritionist, a support group, or a trusted friend, having people to encourage and guide you makes a difference.
You’re More Than a Number
If you notice some weight coming back after stopping GLP-1 meds, please don’t be hard on yourself. Weight regain is a common biological response, not a failure. The skills and habits you build now will help you maintain your health and well-being over the long term. And remember, your healthcare team is there to support you with options, whether that means restarting medication or focusing on lifestyle strategies.
You’ve already taken important steps by learning and caring for yourself. Keep going gently and confidently—you’ve got this.
References and Further Reading
1. Rodriguez PJ et al., JAMA Network Open, 2025. Study on GLP-1 discontinuation and reinitiation patterns in over 125,000 adults with overweight or obesity. Available at: https://www.truveta.com/blog/research/stopping-restarting-glp1-jama/
2. American Association of Clinical Endocrinology Annual Meeting, 2025. SURMOUNT-1 post hoc analysis on tirzepatide discontinuation and weight regain. Summary: https://www.endocrinologyadvisor.com/reports/tirzepatide-discontinuation-reduces-cardiometabolic-benefits/
3. Oxford meta-analysis on weight regain after stopping GLP-1 receptor agonists, 2025. Overview: https://www.linkedin.com/posts/michael-albert-md-b73a8962_obesitycare-glp1-tirzepatide-activity-7329603441004019712-laUV
4. Nutritional priorities to support GLP-1 therapy, 2025. PubMed: https://pubmed.ncbi.nlm.nih.gov/40445127/
5. Digital weight loss clinic study on tapering semaglutide, 2024. Article: https://www.pharmacist.com/Blogs/CEO-Blog/Article/coming-off-glp-1s-slowly-could-be-key-to-preventing-weight-regain
6. Mindful eating and calorie intake, Appetite, 2025. Summary: https://www.foodtimes.eu/consumer-en/minful-eating-mediterranean-diet-and-health/